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The authors did caution that exercise was carried out in a thermoneutral environment and additional research is warranted to determine effects in a more stressful environmental condition [86]

Several antioxidant therapies have showed potential in preserving the BBB in the context of I/R injury

Apoptosis 24(12):320 Peixoto CA, Oliveira WH, Araujo S et al (2017) AMPK activation: role in the signaling pathways of neuroinflammation and neurodegeneration